Zhonghua yi xue za zhi · 1997
[Expression of Cath-D, P-gp and Her-2 in carcinoma of the cardia].
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Zhang L, He L, Huang X
Аннотация
OBJECTIVE: To investigate if Cath-D, P-gp and Her-2 are correlated with prognosis in patients with cardiac carcinoma.
METHODS: Histological sections of 43 patients with cardiac cancer were tested by immunohistochemistry and analyzed for pathological type and lymphatic metastasis.
RESULTS: The research show and that P-gp and Her-2 were not significant in predicting lymphatic metastasis (P > 0.05), but Cath-D positive was significant in lymphatic metastasis (P < 0.01). The P-gp and Cath-D were not significant in differential level of cardiac carcinoma and expression of Her-2 was significant (P < 0.05).
CONCLUSION: The results suggest that positive Cath-D is correlated with metastases and positive Her-2 indicates poor survival. Special treatment plans for patients with carcinoma of the cardia should be designed depending on the above marker tests.
METHODS: Histological sections of 43 patients with cardiac cancer were tested by immunohistochemistry and analyzed for pathological type and lymphatic metastasis.
RESULTS: The research show and that P-gp and Her-2 were not significant in predicting lymphatic metastasis (P > 0.05), but Cath-D positive was significant in lymphatic metastasis (P < 0.01). The P-gp and Cath-D were not significant in differential level of cardiac carcinoma and expression of Her-2 was significant (P < 0.05).
CONCLUSION: The results suggest that positive Cath-D is correlated with metastases and positive Her-2 indicates poor survival. Special treatment plans for patients with carcinoma of the cardia should be designed depending on the above marker tests.