Obesity surgery · 2019
Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation.
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Kashihara Hideya, Shimada Mitsuo, Yoshikawa Kozo, Higashijima Jun, Miyatani Tomohiko, Tokunaga Takuya, Nishi Masaaki, Takasu Chie
Аннотация
BACKGROUND: The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog.
METHODS: Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery.
RESULTS: The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group.
CONCLUSIONS: In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.
METHODS: Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery.
RESULTS: The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group.
CONCLUSIONS: In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.