Медицинская библиотека · Obesity surgery · 2019

Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation.

Kashihara Hideya, Shimada Mitsuo, Yoshikawa Kozo, Higashijima Jun, Miyatani Tomohiko, Tokunaga Takuya, Nishi Masaaki, Takasu Chie

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Аннотация

BACKGROUND

The aim of this study was to investigate gut inflammation and permeability in rats after duodenal-jejunal bypass (DJB) and in rats injected with a glucagon-like peptide-1 (GLP-1) receptor analog.

METHODS

Twelve male 16-week-old obese diabetic rats were divided into three groups: the DJB group, the sham group, and the group injected daily with a GLP-1 receptor agonist (liraglutide). Gut inflammation and the expression of tight junction protein (claudin-1) were analyzed in the three groups at 8 weeks after surgery.

RESULTS

The DJB group showed significantly lower levels of gut inflammatory cytokines than the liraglutide group. Claudin-1 showed stronger intensity on immunofluorescent staining in the DJB group than that in the liraglutide group.

CONCLUSIONS

In summary, DJB surgery might maintain gut permeability via suppression of gut inflammation.

Для цитирования: Kashihara Hideya, Shimada Mitsuo, Yoshikawa Kozo, Higashijima Jun, Miyatani Tomohiko, Tokunaga Takuya, Nishi Masaaki, Takasu Chie. Duodenal-Jejunal Bypass Maintains Gut Permeability by Suppressing Gut Inflammation.. Obesity surgery. 2019. DOI: 10.1007/s11695-019-03922-4.

Предметные рубрики MeSH

Animals Cytokines Disease Models, Animal Duodenum Gastric Bypass Inflammation Intestinal Absorption Jejunum Male Obesity Rats

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