The anti-skin-aging effect of oral administration of gelatin from the swim bladder of Amur sturgeon (Acipenser schrenckii).

Gelatin was extracted from the swim bladder of Amur sturgeon with hot water at 50 °C with acceptable yield (76.54%) and it showed type I collagen features. The degree of hydrolysis reached 70.42%, and 26.55% of collagen peptides (380.76 Da) survived, after simulating digestion, absorption and peripheral blood circulation in vitro. In situ single-pass intestinal perfusion showed that the AMW of the collagen peptides was about 1100 Da in the intestine and they were mainly absorbed in the jejunum (61.11%). A 12-month feeding experiment using rats demonstrated that gelatin improved the histological structure, increased the thickness of the dermis (18.45%) and the density of collagen fibers (22.17%), and decreased the ratio of type III to type I collagen (43.44%) of chronologically aged skin at 3.85 g per kg bw per d. Moreover, the antioxidant enzyme activities in skin were significantly enhanced, while the malondialdehyde content was reduced by 31.99%. These results provided new insights into the development of new nutraceuticals and functional foods for the anti-skin-aging effect.