Head & neck · 2011
Genomic profiling of sinonasal squamous cell carcinoma.
Сравнительное исследованиеСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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López Fernando, Llorente José L, García-Inclán Cristina, Alonso-Guervós Marta, Cuesta-Albalad Mari Paz, Fresno Manuel Florentino, Alvarez-Marcos César, Suárez Carlos, Hermsen Mario A
Аннотация
BACKGROUND: Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SCC.
METHODS: DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.
RESULTS: Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.
CONCLUSION: The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.
METHODS: DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features.
RESULTS: Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13.
CONCLUSION: The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology.
Предметные рубрики MeSH
AgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellComparative Genomic HybridizationDNA Copy Number VariationsDiagnosis, DifferentialFemaleFollow-Up StudiesGene AmplificationGenes, p53GenomeHead and Neck NeoplasmsHumansMaleMaxillary Sinus NeoplasmsMicroarray AnalysisMiddle AgedMutationNose NeoplasmsPrognosisRetrospective StudiesRisk FactorsSurvival AnalysisTreatment Outcome