Developmental biology · 2011
The FaceBase Consortium: a comprehensive program to facilitate craniofacial research.
СтатьяПоддержка NIH: внешняя программаНазвание и аннотация: Перевод пока не подготовлен
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Hochheiser Harry, Aronow Bruce J, Artinger Kristin, Beaty Terri H, Brinkley James F, Chai Yang, Clouthier David, Cunningham Michael L, Dixon Michael, Donahue Leah Rae, Fraser Scott E, Hallgrimsson Benedikt, Iwata Junichi, Klein Ophir, Marazita Mary L, Murray Jeffrey C, Murray Stephen, de Villena Fernando Pardo-Manuel, Postlethwait John, Potter Steven, Shapiro Linda, Spritz Richard, Visel Axel, Weinberg Seth M, Trainor Paul A
Аннотация
The FaceBase Consortium consists of ten interlinked research and technology projects whose goal is to generate craniofacial research data and technology for use by the research community through a central data management and integrated bioinformatics hub. Funded by the National Institute of Dental and Craniofacial Research (NIDCR) and currently focused on studying the development of the middle region of the face, the Consortium will produce comprehensive datasets of global gene expression patterns, regulatory elements and sequencing; will generate anatomical and molecular atlases; will provide human normative facial data and other phenotypes; conduct follow up studies of a completed genome-wide association study; generate independent data on the genetics of craniofacial development, build repositories of animal models and of human samples and data for community access and analysis; and will develop software tools and animal models for analyzing and functionally testing and integrating these data. The FaceBase website (http://www.facebase.org) will serve as a web home for these efforts, providing interactive tools for exploring these datasets, together with discussion forums and other services to support and foster collaboration within the craniofacial research community.