Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockade.

OBJECTIVE

To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.

SUBJECTS AND

METHODS

The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo.

RESULTS

Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin.

CONCLUSIONS

The urinary side-effects of khat chewing are probably mediated through stimulation of alpha 1-adrenergic receptors.