Archives of pathology & laboratory medicine · 2007
Best practices in diagnostic immunohistochemistry: pleomorphic cutaneous spindle cell tumors.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
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Folpe Andrew L, Cooper Kumarasen
Аннотация
CONTEXT: Pleomorphic cutaneous spindle cell tumors can be difficult to distinguish solely on histologic grounds. The use of ancillary immunohistochemical studies can greatly assist in this differential diagnosis.
OBJECTIVE: To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis.
DATA SOURCES: English-language literature published between 1981 and 2005.
CONCLUSIONS: A basic immunohistochemistry panel for high-molecular-weight cytokeratin, melanocytic markers (S100 protein, HMB-45, Melan-A), smooth muscle actin, desmin, and endothelial markers (CD31, CD34) is effective in diagnosing most cutaneous spindle cell tumors.
OBJECTIVE: To review histologic and immunohistochemical aspects of cutaneous spindle cell tumors and discuss a basic panel of markers to assist in the differential diagnosis.
DATA SOURCES: English-language literature published between 1981 and 2005.
CONCLUSIONS: A basic immunohistochemistry panel for high-molecular-weight cytokeratin, melanocytic markers (S100 protein, HMB-45, Melan-A), smooth muscle actin, desmin, and endothelial markers (CD31, CD34) is effective in diagnosing most cutaneous spindle cell tumors.