Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University · 2001
[Expression of bcl-2 protein in uterine leiomyomas and normal myometrium].
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Zhang Z L, Zhang Y, Xu B Q
Аннотация
OBJECTIVE: To study the expression of the apoptosis regulatory protein bcl-2 in the uterine leiomyomas and in the normal myometrium.
METHODS: The expression of bcl-2 protein was examined by immunohistochemical ABC staining in 40 cases of uterine leiomyomas and normal myometrium.
RESULTS: bcl-2 expression was higher in the uterine leiomyomas than that in the normal myometrium, both in the proliferative phase and in the secretory phase of the menstrual cycle (P < 0.01); bcl-2 expression in leiomyomas in the secretory phase was stronger than that in the proliferative phase of the menstrual cycle (P < 0.01).
CONCLUSIONS: The increase of apoptosis inhabiting gene bcl-2 may play an important role in the growth of the uterine leiomyomas. This action may be regulated by progesterone.
METHODS: The expression of bcl-2 protein was examined by immunohistochemical ABC staining in 40 cases of uterine leiomyomas and normal myometrium.
RESULTS: bcl-2 expression was higher in the uterine leiomyomas than that in the normal myometrium, both in the proliferative phase and in the secretory phase of the menstrual cycle (P < 0.01); bcl-2 expression in leiomyomas in the secretory phase was stronger than that in the proliferative phase of the menstrual cycle (P < 0.01).
CONCLUSIONS: The increase of apoptosis inhabiting gene bcl-2 may play an important role in the growth of the uterine leiomyomas. This action may be regulated by progesterone.