Proceedings of the National Academy of Sciences of the United States of America · 2021
Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Luo Wenshu, Egger Matteo, Domonkos Andor, Que Lin, Lukacsovich David, Cruz-Ochoa Natalia Andrea, Szőcs Szilárd, Seng Charlotte, Arszovszki Antónia, Sipos Eszter, Amrein Irmgard, Winterer Jochen, Lukacsovich Tamás, Szabadics János, Wolfer David P, Varga Csaba, Földy Csaba
Аннотация
Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal mossy fiber sprouting to gain insight into wiring mechanisms in mature circuits. We found that sole ectopic expression of Id2 in granule cells is capable of driving mossy fiber sprouting in healthy adult mouse and rat. Mice with the new mossy fiber circuit solved spatial problems equally well as controls but appeared to rely on local rather than global spatial cues. Our results demonstrate reprogrammed connectivity in mature neurons by one defined factor and an assembly of a new synaptic circuit in adult brain.