[Rinsho ketsueki] The Japanese journal of clinical hematology · 2009
POEMS syndrome complicated by follicular lymphoma.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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SASAKI Takahide, OHNISHI Shunsuke, ONISHI Reizo, TAKEMURA Ryou, KOBAYASHI Yoshimitsu, SUZUKI Mio, DAZAI Masayoshi, HATA Tamotsu, YAMAMOTO Junji, ODA Hisashi, TAKAHASHI Tatsuro, OGASAWARA Kazuhiro, MIYAGISHIMA Takuto
Аннотация
A 59-year-old woman presented with ascites and intraperitoneal lymph node swelling. Pathological examination of the lymph node revealed follicular lymphoma. After a lymph node biopsy, she developed atypical genital bleeding, multiple endocrine disorders, polyneuropathy with a high plasma level of vascular endothelial growth factor (VEGF), and was diagnosed with POEMS syndrome. Following administration of methyl prednisolone, ascites immediately decreased and her performance status improved; however, about 18 months later, renal failure occurred, and she died despite increased steroid dosage. Lymph node swelling is often found in POEMS syndrome; however, its histological appearance is not well known, and it is very rare to be concomitant with malignant lymphoma. Therefore, it is important to perform a lymph node biopsy and investigate it in relation with VEGF.