Cancers · 2025
Neurotrophins as Potential Biomarkers for Active Disease and Poor Outcome in Pediatric Acute Lymphoblastic Leukemia.
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de Andrade Karine Pereira, Michaelsen Gustavo Lovatto, Dutra Lívia Fratini, Marques Rebeca Ferreira, Benincasa Daniela Elaine Roth, Portich Júlia Plentz, Loss Jiseh Fagundes, Gregianin Lauro José, Brunetto André Tesainer, Sinigaglia Marialva, Roesler Rafael, da Cunha Jaeger Mariane, Land Marcelo, de Farias Caroline Brunetto
Аннотация
BACKGROUND: Neurotrophins (NTs) are pivotal growth factors in cellular development and survival. Their precise implications in Acute Lymphoblastic Leukemia (ALL) remain unclear.
METHODS: Pediatric ALL samples (2011-2021) were analyzed from a Southern Brazil cohort. Neurotrophin levels were quantified via ELISA, with survival analysis using Kaplan-Meier curves. Gene expression data were sourced from public genomic repositories and analyzed with R software version 4.0.5.
RESULTS: At diagnosis, pro-BDNF, BDNF, and NGF levels were significantly lower than in healthy controls. Reduced pro-BDNF correlated with unfavorable outcomes. NGF and sortilin were highly expressed in healthy samples, while BDNF and p75NTR were predominant in T-ALL and B-ALL, respectively.
CONCLUSIONS: Neurotrophins show significant alterations in the tumor microenvironment of pediatric ALL. Further studies are needed to elucidate their precise role and prognostic potential.
METHODS: Pediatric ALL samples (2011-2021) were analyzed from a Southern Brazil cohort. Neurotrophin levels were quantified via ELISA, with survival analysis using Kaplan-Meier curves. Gene expression data were sourced from public genomic repositories and analyzed with R software version 4.0.5.
RESULTS: At diagnosis, pro-BDNF, BDNF, and NGF levels were significantly lower than in healthy controls. Reduced pro-BDNF correlated with unfavorable outcomes. NGF and sortilin were highly expressed in healthy samples, while BDNF and p75NTR were predominant in T-ALL and B-ALL, respectively.
CONCLUSIONS: Neurotrophins show significant alterations in the tumor microenvironment of pediatric ALL. Further studies are needed to elucidate their precise role and prognostic potential.