The prognostic value of sex hormone receptors expression in laryngeal carcinoma.

Laryngeal cancer was identified as the second most common respiratory system malignancy with squamous cell carcinoma being the most common malignant tumor of the larynx. Larynx being a secondary sex organ showing physiological changes during puberty, raises inquiry about the relationship between sex hormones receptors as estrogen receptors (ER), progesterone receptors (PR), androgen receptors (AR) and the development of laryngeal carcinoma. This study was carried out in cancer tissue samples from 50 patients with laryngeal squamous cell carcinoma. Immunohistochemical staining using ER-β, PR, and AR was carried out. The immunohistochemical expression of ER-β, PR and AR was positive in 56%, 50% and 64% of cases respectively. ER-β, and PR expression were significantly higher in poorly differentiated cases and cases with lymphatic invasion while AR expression was significantly lower in poorly differentiated cases and with lymphatic invasion. In conclusion, ER-β and PR may be considered as markers for poor biological behavior of laryngeal carcinoma.