A rare case of B-cell acute lymphoblastic leukemia with translocation (14;14)(q11.2;q32) involving IGH and CEBPE with review of the literature.

Translocation (14;14)(q11;q32) with immunoglobulin heavy chain (IGH) (14q32) and CCAAT enhancer-binding protein (CEBPE) (14q11) involvement is a rare cytogenetic aberration in B-cell acute lymphoblastic leukemia/lymphoma (B-ALL) associated with a favorable prognosis. This study compares the genetic profile and outcome of a new case with previously reported cases of B-ALL with t(14;14)(q11;q32). In the context of routine diagnostic procedure, a case of B-ALL with t(14;14)(q11;q32) and IGH-CEBPE fusion was identified in a 53-year-old female. The patient achieved complete remission (CR) during induction chemotherapy and remained stable on maintenance therapy for 8 months before passing away from infectious complications, without evidence of leukemic disease. The rapid and sustained treatment response supports the concept that t(14;14)(q11;q32) with IGH and CEBPE involvement may represent a novel B-ALL subgroup distinguished by a favorable prognosis.