Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study.
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Gilligan Gerardo, Panico René, Lazos Jerónimo, Morelatto Rosana, Belardinelli Paola, Criscuolo Maria Ines, Bolesina Nicolas, Molina Ávila Ignacio, Pimentel Solá Juan Martin, Rivarola Emilce, Morgante Maria Jimena, Ingrassia Tonelli Maria Eugenia, Gimenez Javier, Doratti Pablo, Werner Laura Cecilia, Prado-Ribeiro Ana Carolina, Brandão Thais Bianca, Vechiato-Filho Aljomar Jose, Cuzzullin Maria Claudia, Saldivia-Siracusa Cristina, Lopes Marcio Ajudarte, Agostini Michelle, Romañach Mario José, Abrahão Aline Corrêa, Fonsêca Thamyres Campos, Kaminagakura Estela, Anbinder Ana Lia, Santos Alves Kamilla, de Almeida Lança Maria Leticia, Sacsaquispe-Contreras Sonia, Rodriguez Ibazetta Karem, Gerber-Mora Roberto, Aranda Romo Saray, Tejeda Nava Francisco Javier, Cordero-Torres Karina, Moreno Silva Ricardo, Gonzalez-Arriagada Wilfredo, Toro Raiza, Silveira Felipe Martins, Gonzalez Natalia, Vargas Pablo Agustin, Santos-Silva Alan Roger, Bologna-Molina Ronell, Villarroel-Dorrego Mariana, Martinez Benjamin, Piemonte Eduardo
Аннотация
METHODS: A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential-OSCC versus OSCC-de novo (OSCC-dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's t-test, and qualitative variables with chi-square.
RESULTS: In total, 2705 OSCC were included with a mean age of 62.8 years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC-dn, while s-OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD.
CONCLUSIONS: In Latin America, OSCC-dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.