Archives of physical medicine and rehabilitation · 2004
Differential cerebellar activation on functional magnetic resonance imaging during working memory performance in persons with multiple sclerosis.
Клиническое исследованиеСтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Li Yali, Chiaravalloti Nancy D, Hillary Frank G, Deluca John, Liu Wen-Ching, Kalnin Andrew J, Ricker Joseph H
Аннотация
OBJECTIVE: To explore the potential role of the cerebellum in working memory dysfunction in multiple sclerosis (MS).
DESIGN: Blood oxygen level dependent functional magnetic resonance imaging (fMRI) was used to examine cerebellar activation during a working memory task.
SETTING: University-affiliated medical rehabilitation facility.
PARTICIPANTS: Eight persons with MS and 5 healthy controls.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Change in hemodynamic response. fMRI data were acquired and subsequently analyzed by using Statistical Parametric Mapping.
RESULTS: Both the control and MS groups showed significantly greater activations in the right cerebellar hemisphere as compared with the left side. Persons with MS, however, showed no detectable activations in 4 cerebellar substructures that were significantly active in controls (ie, right vermis, right dentate nucleus, right tonsil, cerebellar peduncle).
CONCLUSIONS: The significantly decreased cerebellar activation in the MS group suggests that the cerebellum may play a role in the working memory impairment observed in MS.
DESIGN: Blood oxygen level dependent functional magnetic resonance imaging (fMRI) was used to examine cerebellar activation during a working memory task.
SETTING: University-affiliated medical rehabilitation facility.
PARTICIPANTS: Eight persons with MS and 5 healthy controls.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: Change in hemodynamic response. fMRI data were acquired and subsequently analyzed by using Statistical Parametric Mapping.
RESULTS: Both the control and MS groups showed significantly greater activations in the right cerebellar hemisphere as compared with the left side. Persons with MS, however, showed no detectable activations in 4 cerebellar substructures that were significantly active in controls (ie, right vermis, right dentate nucleus, right tonsil, cerebellar peduncle).
CONCLUSIONS: The significantly decreased cerebellar activation in the MS group suggests that the cerebellum may play a role in the working memory impairment observed in MS.