ORL; journal for oto-rhino-laryngology and its related specialties · 2009
Recurrent cancer of the parotid gland: how well does salvage surgery work for locoregional failure?
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Kobayashi Kenya, Nakao Kazunari, Yoshida Masafumi, Ando Mizuo, Ebihara Yasuhiro, Asakage Takahiro, Yamasoba Tatsuya
Аннотация
PURPOSE: Many articles have discussed the clinical features of previously untreated parotid cancer, but the clinical characteristics and treatment of recurrent parotid cancer have not yet been fully described.
MATERIALS: We retrospectively reviewed 20 patients with recurrent parotid cancer and analyzed the therapeutic strategies and the prognostic factors.
RESULTS: Twelve patients (60%) underwent definitive surgery, including 3 who underwent skull base surgery. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) in the surgery group were 66.7 and 64.1%. In the definitive surgery group, the presence of lymph node metastasis and high-grade malignant histopathology were associated with a poor prognosis (p < 0.01). On the other hand, the presence of facial palsy at presentation, the surgical margin, the time of relapse and the T stage did not affect the DFS in our series.
CONCLUSIONS: The results suggest that aggressive definitive surgery may be justified for the treatment of recurrent parotid cancer. The presence of lymph node metastasis and the histopathological malignancy grade are poor prognostic factors for OS and DFS.
MATERIALS: We retrospectively reviewed 20 patients with recurrent parotid cancer and analyzed the therapeutic strategies and the prognostic factors.
RESULTS: Twelve patients (60%) underwent definitive surgery, including 3 who underwent skull base surgery. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) in the surgery group were 66.7 and 64.1%. In the definitive surgery group, the presence of lymph node metastasis and high-grade malignant histopathology were associated with a poor prognosis (p < 0.01). On the other hand, the presence of facial palsy at presentation, the surgical margin, the time of relapse and the T stage did not affect the DFS in our series.
CONCLUSIONS: The results suggest that aggressive definitive surgery may be justified for the treatment of recurrent parotid cancer. The presence of lymph node metastasis and the histopathological malignancy grade are poor prognostic factors for OS and DFS.
Предметные рубрики MeSH
AdenocarcinomaAdenoma, OxyphilicAdultAgedAged, 80 and overCarcinoma, Adenoid CysticCarcinoma, MucoepidermoidFacial ParalysisFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasms, Glandular and EpithelialParotid NeoplasmsPrognosisRetrospective StudiesSalvage TherapySkull Base