Journal of ethnopharmacology · 2025
Comparative study on the toxicity of Polygoni Multiflori Radix: Assessment of decoction extract and powder in single-dose and 13-week repeated-dose toxicity studies in Sprague-Dawley rats.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Min Seung Eui, Jang Min Seong, Lee Byoung-Seok, Kim Woojin, Kim Yong-Bum, Min Byung Sun, Kim Jeong Ah, Han Kang-Hyun
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Polygoni Multiflori Radix (PMR) is a traditional Chinese herbal medicine widely used for its biological activities. PMR's major components vary by extract form. However, toxicity studies on PMR decoction extract and powder are needed to ensure its safe use.
AIM OF THE STUDY: This study aimed to evaluate the single and repeated administration toxicity studies of PMR decoction extract and powder.
MATERIALS AND METHODS: Both test items were orally administered to SD rats at doses of 0, 1000, 2000, and 5000 mg/kg for the single-dose, and doses of 0, 313, 625, 1250, 2500, and 5000 mg/kg/day for the 13-week repeated-dose toxicity studies.
RESULTS: The single-dose toxicity study showed no mortality, changes in body weight, clinical signs, or macroscopic findings, with the approximate lethal dose of both test items exceeding 5000 mg/kg. The 13-week repeated-dose toxicity study showed no treatment-related changes in body weight, food consumption, ophthalmology, or macroscopic findings in both test items. In histopathology, stomach hyperplasia occurred at 5000 mg/kg/day in both sexes for PMR decoction extract and in males for PMR powder. Basophilia of tubules was observed in the kidneys of males at 5000 mg/kg/day in the PMR decoction extract group. Therefore, the no observed adverse effect level of PMR decoction extract was set to 2500 mg/kg/day and PMR powder was set to 2500 mg/kg/day for males and exceeded 5000 mg/kg/day for females.
CONCLUSIONS: This study establishes the non-toxic doses of PMR decoction extract and powder, determining the non-toxic dose levels based on the different extract forms.
AIM OF THE STUDY: This study aimed to evaluate the single and repeated administration toxicity studies of PMR decoction extract and powder.
MATERIALS AND METHODS: Both test items were orally administered to SD rats at doses of 0, 1000, 2000, and 5000 mg/kg for the single-dose, and doses of 0, 313, 625, 1250, 2500, and 5000 mg/kg/day for the 13-week repeated-dose toxicity studies.
RESULTS: The single-dose toxicity study showed no mortality, changes in body weight, clinical signs, or macroscopic findings, with the approximate lethal dose of both test items exceeding 5000 mg/kg. The 13-week repeated-dose toxicity study showed no treatment-related changes in body weight, food consumption, ophthalmology, or macroscopic findings in both test items. In histopathology, stomach hyperplasia occurred at 5000 mg/kg/day in both sexes for PMR decoction extract and in males for PMR powder. Basophilia of tubules was observed in the kidneys of males at 5000 mg/kg/day in the PMR decoction extract group. Therefore, the no observed adverse effect level of PMR decoction extract was set to 2500 mg/kg/day and PMR powder was set to 2500 mg/kg/day for males and exceeded 5000 mg/kg/day for females.
CONCLUSIONS: This study establishes the non-toxic doses of PMR decoction extract and powder, determining the non-toxic dose levels based on the different extract forms.