F1000Research · 2025
In vitro antitumor capacity of extracts obtained from the plants Plukenetia volubilis (Sacha inchi) and Moringa oleifera in gastric cancer.
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Vargas Jose, Arbelaez Natalia, Cardenas Denny, Murillo Javier, Ospina Victoria, Robledo Sara, Soto Javier
Аннотация
BACKGROUND: Gastric cancer is the fifth most common cancer and the third leading cause of cancer deaths worldwide. Perioperative or adjuvant chemotherapy improves survival in patients with stage 1B or higher cancers. Moringa oleifera and Plukenetia volubilis (Sacha inchi) have been reported to enhance various biological functions, including antitumor and antiproliferative activity.
METHODS: In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of P.volubilis, the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).
RESULTS: All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations . P. volubilis seed oil showed 95% mortality at 1% concentration (CC 50 = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the P. volubilis oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic M. oleifera leaf extract also inhibited cell migration.
CONCLUSION: M. oleifera, P. volubilis leaf extracts and P. volubilis seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.
METHODS: In order to evaluate this potential present in crude extracts of the leaves of these plants, as well as the seed oil of P.volubilis, the antitumor activity was determined according to the effect of these derivatives on different biological parameters such as cytotoxicity, proliferation, cell cycle, apoptosis (among others), in AGS cells (CRL-1739).
RESULTS: All extracts tested were cytotoxic at 90 and 160 μg/ml concentrations . P. volubilis seed oil showed 95% mortality at 1% concentration (CC 50 = 46.7%). Cell proliferation was inhibited, and all extracts affected the cell cycle, but the P. volubilis oil significantly induced an accumulation of AGS cells in the sub G1 phase, inducing DNA fragmentation as a mechanism of cell death. The ethanolic M. oleifera leaf extract also inhibited cell migration.
CONCLUSION: M. oleifera, P. volubilis leaf extracts and P. volubilis seed oil can potentially be antitumor products. Further validation in a murine model of gastric cancer is needed to investigate the antitumor potential of these extracts further and to continue the development of herbal products that can help in the management of this type of tumor.