Thymus vulgaris Attenuates Myleran-induced Reproductive Damage by Decreasing Oxidative Stress and Lipid Peroxidation in Male Rats.

CONTEXT: Thymus vulgaris is an herbal with potent antioxidant and it has been shown to have beneficial effects during short-term administration. Myleran (MYL) is used for treatment of certain types of tumors. MYL produces free radicals and induces disturbance in sperm parameters.

AIMS: This study is designed to assess the effects of T. vulgaris against damage to the male rats' reproductive features induced by MYL.

SUBJECTS AND

METHODS

Sixty-four male Wistar rats were randomly assigned into eight groups: control group; MYL (10 mg/kg) group; T. vulgaris groups (4.5, 9, and 18 mg/kg); and MYL (10 mg/kg) + T. vulgaris groups (4.5, 9, and 18 mg/kg; separately). Treatments were administered daily intraperitoneal injection for 60 days. Total antioxidant capacity, sperm factors, malondialdehyde (MDA), testosterone, and germinal layer height were analyzed.

RESULTS

Whole variables of MYL group decreased signifcantly compared to the control group (P < 0.05) except MDA level (which increased). The T. vulgaris and T. vulgaris + MYL treatments in all doses increased all parameters significantly except MDA level (which decreased) compared to the MYL group (P < 0.05). No significant modifications were observed in all T. vulgaris groups compared to the control group (P > 0.05).

CONCLUSIONS

T. vulgaris reduces the poisonous properties of MYL on male reproductive factors.