Fertility and sterility · 2011
Is the baboon model appropriate for endometriosis studies?
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Dehoux Jean-Paul, Defrère Sylvie, Squifflet Jean, Donnez Olivier, Polet Roland, Mestdagt Mélanie, Foidart Jean-Michel, Van Langendonckt Anne, Donnez Jacques
Аннотация
OBJECTIVE: To determinethe prevalence of spontaneous endometriosis andthe incidence of induced endometriosis after endocervical canal resection in baboons.
DESIGN: Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection.
SETTING: Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium.
ANIMAL(S): Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis.
INTERVENTION(S): A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection.
MAIN OUTCOME MEASURE(S): Follow-up by laparoscopy.
RESULT(S): Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29).
CONCLUSION(S): The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation.
DESIGN: Induction and follow-up of endometriosis in baboons, which is one of the primate species that develop spontaneous endometriosis. Forty-one baboons were checked for the presence of spontaneous endometriosis. We then attempted to induce endometriosis in 30 of them by endocervical canal resection.
SETTING: Institute of Primate Research, Nairobi, Kenya, and Catholic University of Louvain, Brussels, Belgium.
ANIMAL(S): Forty-one baboons were checked for spontaneous endometriosis and 30 of them were used to develop a model of induced endometriosis.
INTERVENTION(S): A total of 41 baboons underwent diagnostic laparoscopy for 10 months. In a first step, 30 of this number subsequently underwent endocervical canal resection. In a second step, 20 of the 30 underwent uterine horn resection.
MAIN OUTCOME MEASURE(S): Follow-up by laparoscopy.
RESULT(S): Two of the 41 baboons were diagnosed with spontaneous endometriosis (4.8%). Twelve months after the surgical procedure to induce endometriosis, 8 of 29 animals presented with endometriotic lesions diagnosed by using laparoscopy and confirmed by histologic examination. The incidence of induced endometriosis in our model was thus 27.6%. In 2 baboons, endometriosis disappeared over time, resulting in a final rate of 20.7% (6/29).
CONCLUSION(S): The rate of spontaneous endometriosis is very low (4.8%). Endometriosis can be induced (with a rate of just 27.6%) by endocervical canal resection to stimulate retrograde menstruation.