Specific features of biogenic amine content in the cerebral cortex during experimental intracerebral hemorrhage in rats with various behavioral characteristics.

Experiments on Wistar rats showed that modeling of hemorrhage in the left caudate nucleus of the brain in behaviorally passive specimens is mainly accompanied by an increase in biogenic amine content in the sensorimotor cortex of the right cerebral hemisphere (particularly on day 3 after the surgery). Norepinephrine content in the sensorimotor cortex of the right cerebral hemisphere in behaviorally active rats was reduced over 7 days after the development of intracerebral hemorrhage. The contents of dopamine and serotonin in brain tissue of behaviorally active animals most significantly increased on day 7 after experimental stroke. Our results indicate that experimental hemorrhage in the left caudate nucleus of rats with various behavioral characteristics is accompanied by specific changes in biogenic amine content in the sensorimotor cortex of the right cerebral hemisphere. We conclude that neurochemical processes in brain structures distant from the site of hemorrhage play an important role in the pathogenesis of hemorrhagic stroke.