Therapeutic advances in endocrinology and metabolism · 2025
Triglyceride-glucose index and lipid ratios in women with and without polycystic ovary syndrome: a systematic review and meta-analysis.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ulloque-Badaracco Juan R, Alarcon-Braga Esteban A, Hernandez-Bustamante Enrique A, Cabrera-Guzmán Juan C, Dotto-Vasquez Giuseppe, Maldonado-Basurto Gian F, Rivera-Cabrera Germán, Maita-Arauco Sherelym H, Horruitiner-Mendoza Andres A, Herrera-Añazco Percy, Benites-Zapata Vicente A, Pérez-López Faustino R
Аннотация
BACKGROUND: The pathophysiology of polycystic ovary syndrome (PCOS) is complex and heterogeneous. This systematic review and meta-analysis aimed to determine the triglyceride-glucose index and lipid ratios in women with and without PCOS.
METHODS: Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride-glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs).
RESULTS: The search identified 61 observational studies, including case-control (n = 37), cohort (n = 2), and cross-sectional (n = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared with the control group, the PCOS group presented increased circulating triglyceride-glucose index (n = 9 studies, SMD, 0.41; 95% CI, 0.08-0.74) and total cholesterol/HDL-cholesterol (n = 35 studies, SMD, 1.70; 95% CI, 0.69-2.70), triglyceride/HDL-cholesterol (n = 31 studies; SMD, 0.81; 95% CI, 0.43-1.19), and LDL-cholesterol/HDL-cholesterol (n = 25 studies, SMD, 2.40; 95% CI, 0.45-4.35) ratios. Statistical heterogeneity values were very high (I 2 > 90%). The PCOS group displayed significantly higher body mass index and homeostatic model assessment of insulin resistance. The PCOS group was younger than the control group and had a higher total cholesterol/HDL-cholesterol ratio, and other lipid variables were comparable in all groups.
CONCLUSION: Patients with PCOS show significantly higher triglyceride-glucose index and total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol ratios than those without the syndrome.
METHODS: Literature searches were performed in PubMed, Scopus, Web of Science, Scielo, and Embase for studies reporting the triglyceride-glucose index and total cholesterol/high-density lipoprotein (HDL)-cholesterol, triglyceride/HDL-cholesterol, and low-density lipoprotein (LDL)-cholesterol/HDL-cholesterol ratios. Results are reported as standardized mean differences (SMDs) along with their 95% confidence intervals (CIs).
RESULTS: The search identified 61 observational studies, including case-control (n = 37), cohort (n = 2), and cross-sectional (n = 22) studies reporting results of interest according to different PCOS diagnosis criteria. Compared with the control group, the PCOS group presented increased circulating triglyceride-glucose index (n = 9 studies, SMD, 0.41; 95% CI, 0.08-0.74) and total cholesterol/HDL-cholesterol (n = 35 studies, SMD, 1.70; 95% CI, 0.69-2.70), triglyceride/HDL-cholesterol (n = 31 studies; SMD, 0.81; 95% CI, 0.43-1.19), and LDL-cholesterol/HDL-cholesterol (n = 25 studies, SMD, 2.40; 95% CI, 0.45-4.35) ratios. Statistical heterogeneity values were very high (I 2 > 90%). The PCOS group displayed significantly higher body mass index and homeostatic model assessment of insulin resistance. The PCOS group was younger than the control group and had a higher total cholesterol/HDL-cholesterol ratio, and other lipid variables were comparable in all groups.
CONCLUSION: Patients with PCOS show significantly higher triglyceride-glucose index and total cholesterol/HDL-cholesterol, triglyceride/HDL-cholesterol, and LDL-cholesterol/HDL-cholesterol ratios than those without the syndrome.