Diagnostic Imaging Characteristics of a Rare Primary Ovarian Mesonephric-Like Adenocarcinoma: A Case Report and Literature Review.

Ovarian mesonephric-like adenocarcinoma is rare and poorly understood, and preoperative diagnosis of this tumor with any diagnostic modality is challenging. Histological features can only be speculated through imaging. Herein, we present the case of a 64-year-old woman with primary ovarian mesonephric-like adenocarcinoma, characterized by a 13 cm pelvic mass detected via ultrasound. Further evaluation with magnetic resonance imaging showed low signal intensity in the solid component on T2-weighted images and high signal intensity on diffusion-weighted images, along with a smooth margin; these findings are consistent with those of previous reports. The patient underwent a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and partial omentectomy. Postoperative pathology confirmed mesonephric-like adenocarcinoma with positive peritoneal cytology. Immunohistochemical analysis showed a positive result for GATA-3 and a negative result for thyroid transcription factor-1. The patient was diagnosed with stage IC3 mesonephric-like adenocarcinoma, and adjuvant chemotherapy with paclitaxel and carboplatin was initiated. Mesonephric-like adenocarcinoma can present with distinct imaging features, including low signal intensity on T2-weighted imaging and high signal intensity on diffusion-weighted imaging, with a smooth solid margin; these imaging features may aid in the preoperative differentiation from other ovarian malignancies, such as serous or clear cell carcinomas.