[How genomics upsets understanding of adrenal tumors?].

How genomics upsets understanding of adrenal tumors ? Adrenal tumors include pheochromocytomas adenomas, hyperplasia and adrenocortical carcinomas. Recently these tumors have been analyzed by genomic approaches, measuring the molecular variability at a large scale, in the DNA sequence, the gene expression, and in the genome structure. From these works came out : new genes responsible for these tumors, which will enable a more accurate diagnosis, family screening, and liquid biopsies (detection of these mutations in the blood) ; the discovery of two main forms of adrenocortical carcinomas, associated with very different prognoses, that will stratify the treatment of patients; and new mechanisms of tumorigenesis, opening the way to new therapeutic perspectives.