Exosomal circRNAs contribute to intestinal development via the VEGF signalling pathway in human term and preterm colostrum.

INTRODUCTION: The report discusses the management of ocular surface complications in the late phase of toxic epidermal necrolysis, with an emphasis on strategies to mitigate these debilitating consequences.

CASE REPORT: A 75-year-old male presented with severe ocular complications, including visual acuity loss, pain, and tearing in the right eye (RE), stemming from chronic-phase Toxic Epidermal Necrolysis (TEN) triggered by allopurinol two years previously. Initial examination revealed cicatricial entropion in both eyes (BE), with the right eye (RE) exhibiting conjunctival cicatrization, symblepharon, corneal neovascularization, and a 3 mm corneal perforation. The patient underwent a combination of surgical and medical interventions, including fornix reconstruction, customized mini-keratoplasty, amniotic membrane transplantation, and partial tarsorrhaphy. Post-operative treatment included topical dexamethasone, tobramycin, cyclosporine, artificial tears, and oral prednisone. Despite ongoing treatment, including the addition of platelet-rich plasma, the right eye's best-corrected visual acuity (BCVA) remained at light perception, with persistent corneal haziness, neovascularization, progressive conjunctival cicatrization, and keratinization.

CONCLUSIONS: This case highlights the significant challenges of managing late-phase ocular complications in SJS/TEN, emphasizing the need for a multidisciplinary approach and aggressive intervention to preserve ocular structure and function.