Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2018
[Clinical Evaluation of A New Pathological Classification for Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree].
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Wang Nana, Jiang Nan, Yang Xiaoqing, Fang Lei, Sun Qing
Аннотация
BACKGROUND: Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree.
METHODS: Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.
RESULTS: Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.
CONCLUSIONS: The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
METHODS: Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as: bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.
RESULTS: Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.
CONCLUSIONS: The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.