Adenocarcinoma of the gastric cardia: prognostic significance of pathologic and treatment factors.

The records of 146 patients who had surgery for adenocarcinoma of the gastric cardia between 1977 and 1992 at National Taiwan University Hospital were retrospectively analyzed. The prognostic significance of pathologic and surgical treatment factors was examined by log rank test and stepwise regression procedures. The overall 2-year and 5-year survival rates were 40.2% and 23.7%, respectively. The pathologic factors analyzed included: age, sex, tumor diameter, esophageal invasion, pathologic grading, vascular invasion, perineural invasion, depth of invasion, node-status, distant metastasis and number of positive lymph nodes. The surgical treatment factors analyzed included:surgical procedure, region of lymphadenectomy, resection margin and resection status. Resection status was classified into three categories: absolute curative, relative curative and palliative. Univariate analyses showed that esophageal invasion, vascular invasion, depth of invasion, node status, node number, resection margin and resection status were significant prognostic factors. The selected stepwise regression model identified three significant independent factors: node status, resection status and esophageal invasion. Aggressive surgical management, including combined resection and extended lymphadenectomy, may be helpful for patients with adenocarcinoma of the gastric cardia.