Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2016
Effects of a Single Dose Dexmedetomidine on Surgical Field Visibility During Middle Ear Microsurgery: A Randomized Study.
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Liu Tingjie, Qin Minju, Li Wenxian, Shen Xia
Аннотация
OBJECTIVES: To investigate whether a single dose of dexmedetomidine (DEX) improves surgical field visibility.
STUDY DESIGN: Randomized, prospective, double-blind study.
SETTING: Tertiary teaching hospital.
INTERVENTIONS: ASA I or II patients undergoing tympanoplasty with ossiculoplasty were randomly assigned to receive either 0.8 μg/kg DEX (Group D) or the same volume of saline (Group N) 10 min before anesthesia induction.
MAIN OUTCOMES: The primary outcome was the visibility of the surgical field rated by surgeons by Boezaart score. The secondary outcomes were consumption of anesthesia, hemodynamic profiles, and subsequent recovery.
RESULTS: Boezaart scores for surgical visibility were lower in Group D than in Group N (1.3 ± 0.8 versus 1.8 ± 0.9, P = 0.014). Minimum alveolar concentrations of sevoflurane (Group D 1 [0.9/1.1] versus Group N 1 [1/1.2], P = 0.018) and remifentanil consumption (Group D 370 [218/504] μg versus Group N 583 [300/1028] μg, P = 0.002) were less in Group D. Except for a transient increase in blood pressure and a decrease in heart rate during DEX infusion, hemodynamic profiles were more stable in Group D than in Group N. More patients needed morphine rescue and presented with postoperative nausea and vomiting in Group N than in Group D (Group D 1 versus Group N 8, P = 0.029). Recovery time was comparable between the two groups (Group D 19 min versus Group N 18 min, P = 0.569).
CONCLUSION: Use of a single dose of DEX resulted in improved surgical visibility, less consumption of anesthesia, and more favorable hemodynamic profile while not delaying recovery time.
STUDY DESIGN: Randomized, prospective, double-blind study.
SETTING: Tertiary teaching hospital.
INTERVENTIONS: ASA I or II patients undergoing tympanoplasty with ossiculoplasty were randomly assigned to receive either 0.8 μg/kg DEX (Group D) or the same volume of saline (Group N) 10 min before anesthesia induction.
MAIN OUTCOMES: The primary outcome was the visibility of the surgical field rated by surgeons by Boezaart score. The secondary outcomes were consumption of anesthesia, hemodynamic profiles, and subsequent recovery.
RESULTS: Boezaart scores for surgical visibility were lower in Group D than in Group N (1.3 ± 0.8 versus 1.8 ± 0.9, P = 0.014). Minimum alveolar concentrations of sevoflurane (Group D 1 [0.9/1.1] versus Group N 1 [1/1.2], P = 0.018) and remifentanil consumption (Group D 370 [218/504] μg versus Group N 583 [300/1028] μg, P = 0.002) were less in Group D. Except for a transient increase in blood pressure and a decrease in heart rate during DEX infusion, hemodynamic profiles were more stable in Group D than in Group N. More patients needed morphine rescue and presented with postoperative nausea and vomiting in Group N than in Group D (Group D 1 versus Group N 8, P = 0.029). Recovery time was comparable between the two groups (Group D 19 min versus Group N 18 min, P = 0.569).
CONCLUSION: Use of a single dose of DEX resulted in improved surgical visibility, less consumption of anesthesia, and more favorable hemodynamic profile while not delaying recovery time.