Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics · 2009
Preclinical animal model for de novo bone formation in human maxillary sinus.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Schlegel Karl Andreas, Rupprecht Stephan, Petrovic Ljubinko, Honert Christian, Srour Safwan, von Wilmowsky Cornelius, Felszegy Endre, Nkenke Emeka, Lutz Rainer
Аннотация
OBJECTIVES: Up to now the effect of bone-substitute materials on de novo bone formation has been tested in a variety of preclinical animal models. We hypothesized that there is no significant difference in bone regeneration after application of autogenous bone (AB) and bone substitutes in a porcine calvarial monocortical defect model and in human maxillary sinus.
STUDY DESIGN: Twenty-four weeks after application of ss-tricalcium phosphate (betaTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11x betaTCP, 6x HA and 24x AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.
RESULTS: Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.
CONCLUSION: The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.
STUDY DESIGN: Twenty-four weeks after application of ss-tricalcium phosphate (betaTCP), hydroxyapatite (HA), and AB in each of 3 defects on the sculls of 6 adult pigs (N = 54) and the application in 44 sinus floor elevations (11x betaTCP, 6x HA and 24x AB) in 41 patients, bone regeneration rates where compared microradiographically. Wilcoxon rank-sum test was used for statistical analysis.
RESULTS: Comparing the human with the animal specimens microradiographically, no significant difference of the mineralization rate could be found.
CONCLUSION: The chosen porcine model is a valuable method for preclinical testing of bone-substitute materials in maxillofacial surgery.
Предметные рубрики MeSH
Alveolar Ridge AugmentationAnimalsBiocompatible MaterialsBone DiseasesBone MatrixBone RegenerationBone SubstitutesBone TransplantationCalcification, PhysiologicCalcium PhosphatesDental Implantation, EndosseousDental ImplantsDisease Models, AnimalDurapatiteFemaleFrontal BoneHumansImage Processing, Computer-AssistedMaleMaxillaMaxillary SinusMicroradiographyMiddle AgedMineralsOsteogenesisSwine