[Tissue specific rescue of lymphomas arose various types of tumors with p53-deficiency].

p53 deficient mice have been found to be highly prone to develop tumors spontaneously. In particular, the thymic lymphoma was observed predominantly, which is not the case for p53-related tumorigenesis in human. To elucidate this differences, I tried to rescue the p53 deficient mice from lymphoma originated in thymus by allowing the p53 expression in their lymphocytes by using transgenic technique. They survived longer than the p53 deficient littermates. In addition, they developed various types of tumors including glioma, medulloblastoma and breast cancer, which have not been observed in p53 deficient mice.