Zhonghua wai ke za zhi [Chinese journal of surgery] · 2002
[Role of interferon alpha in the management of severe acute pancreatitis].
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Tang Yaoqing, Qi Dachuan, Wu Jun, Mao Enqiang, Ji Jun, Han Tianquan, Zhang Shendao
Аннотация
OBJECTIVE: To investigate the efficacy of IFN-alpha on severe acute pancreatitis (SAP) of IFN-alpha.
METHODS: A SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.
RESULTS: Compared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.
CONCLUSION: IFN-alpha has significant curative effect on SAP.
METHODS: A SAP model was developed in adult male rats by retrograde injection of 5% sodium taurocholate in the pancreatic duct. Serum amylase was measured by the blue-starch method and serum cytokines were determined by ELISA.
RESULTS: Compared with to the control group, less pancreatic injury and lower amylase level were observed treat in the rats with IFN-alpha. In contrast, the concentration of IL-10 was higher.
CONCLUSION: IFN-alpha has significant curative effect on SAP.