EuPA open proteomics · 2016
Comparative proteomic analysis of malignant pleural mesothelioma: Focusing on the biphasic subtype.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Giusti Laura, Ciregia Federica, Bonotti Alessandra, Da Valle Ylenia, Donadio Elena, Boldrini Claudia, Foddis Rudy, Giannaccini Gino, Mazzoni Maria R, Canessa Pier Aldo, Cristaudo Alfonso, Lucacchini Antonio
Аннотация
Malignant pleural mesothelioma (MPM) is a rare cancer originated from pleural mesothelial cells. MPM has been associated with long-term exposure to asbestos. In this work we performed a comparative proteomic analysis of biphasic pleural mesothelioma (B-PM). Tissue biopsies were obtained from 61 patients who were subjected to a diagnostic thoracoscopy. 2D/MS based approach was used for proteomic analysis. The 22 proteins found differentially expressed in B-PM, with respect to benign, were analyzed by Ingenuity Pathways Analysis and compared with those obtained for epitheliod pleural mesothelioma (E-PM). A different activation of transcription factors, proteins and cytokines were observed between two subtypes.