Medical archives (Sarajevo, Bosnia and Herzegovina) · 2022
Glutathione Peroxide and Glutathione to Disulfide Glutathione Ratio in Presbycusis: a Case-control Study.
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Hasansulama Wijana, Madiadipoera Teti S, Sunarjati, Garna Herry
Аннотация
BACKGROUND: Presbycusis is a gradual hearing loss caused by the ageing process. This is a chronic condition that affects the elderly population, and sensorineural progressive bilateral symmetry occurs with predominantly high-frequency hearing loss. The ability to discriminate speech decreases; hence, most of the affected patients have conversation problems, especially in noisy environments.This situation is a serious problem among elderly individuals. Social isolation, depression, and paranoia can be related to presbycusis.
OBJECTIVE: The aim of this study was to investigate GPx and the GSH:GSSG ratio as risk factors for presbycusis.
METHODS: A case-control study was conducted to determine the role of GPx activity with the GSH:GSSG ratio as a presbycusis risk factor in 60 subjects aged 55 to 75 years old during the period of August 2012 - April 2014. All of the subjects passed an ENT examination, pure tone audiometry, and tympanometry. The activity of GPx was measured with the Paglia and Valentine method, and the GSH:GSSG ratio was measured by the calorimetric method.
RESULTS: The activity of GPx and the GSH:GSSG ratio were significantly different between the groups (p<0.05), and the odds ratio for high GPx with a low GSH:GSSG ratio was 135 (CI 95%: 5.17-20,028.88).
CONCLUSION: High GPx activity with a low GSH:GSSG ratio is a risk factor for presbycusis.
OBJECTIVE: The aim of this study was to investigate GPx and the GSH:GSSG ratio as risk factors for presbycusis.
METHODS: A case-control study was conducted to determine the role of GPx activity with the GSH:GSSG ratio as a presbycusis risk factor in 60 subjects aged 55 to 75 years old during the period of August 2012 - April 2014. All of the subjects passed an ENT examination, pure tone audiometry, and tympanometry. The activity of GPx was measured with the Paglia and Valentine method, and the GSH:GSSG ratio was measured by the calorimetric method.
RESULTS: The activity of GPx and the GSH:GSSG ratio were significantly different between the groups (p<0.05), and the odds ratio for high GPx with a low GSH:GSSG ratio was 135 (CI 95%: 5.17-20,028.88).
CONCLUSION: High GPx activity with a low GSH:GSSG ratio is a risk factor for presbycusis.