Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2008
Influence of age and histology on outcome in adult non-Hodgkin lymphoma patients undergoing autologous hematopoietic cell transplantation (HCT): a report from the Center For International Blood & Marrow Transplant Research (CIBMTR).
Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
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Lazarus Hillard M, Carreras Jeanette, Boudreau Christian, Loberiza Fausto R, Armitage James O, Bolwell Brian J, Freytes César O, Gale Robert Peter, Gibson John, Hale Gregory A, Inwards David J, LeMaistre Charles F, Maharaj Dipnarine, Marks David I, Miller Alan M, Pavlovsky Santiago, Schouten Harry C, van Besien Koen, Vose Julie M, Bitran Jacob D, Khouri Issa F, McCarthy Philip L, Yu Hongmei, Rowlings Philip, Serna Derek S, Horowitz Mary M, Rizzo J Douglas, Center For International Blood & Marrow Transplant Research (CIBMTR)
Аннотация
To compare the clinical outcomes of older (age > or =55 years) non-Hodgkin lymphoma (NHL) patients with younger NHL patients (<55 years) receiving autologous hematopoietic cell transplantation (HCT) while adjusting for patient-, disease-, and treatment-related variables, we compared autologous HCT outcomes in 805 NHL patients aged > or =55 years to 1949 NHL patients <55 years during the years 1990-2000 using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). In multivariate analysis, older patients with aggressive histologies were 1.86 times (95% confidence interval [CI] 1.43-2.43, P < .001) more likely than younger patients to experience treatment-related mortality (TRM). Relative death risks were 1.33 times (CI 1.04-1.71, P = .024) and 1.50 times (CI 1.33-16.9, P < .001) higher in older compared to younger patients with follicular grade I/II and aggressive histologies, respectively. Autologous HCT in older NHL patients is feasible, but most disease-related outcomes are statistically inferior to younger patients. Studies addressing supportive care particular to older patients, who are most likely to benefit from this approach, are recommended.