Idiotype vaccine strategies for improving outcomes in follicular lymphoma.

BACKGROUND

Follicular lymphoma (FL) is a common indolent lymphoma associated with a relapsing course. Preclinical models and clinical studies demonstrate that immunizing FL patients against their own tumor idiotype induces humoral and cellular immunity and supresses tumor growth.

METHODS

We review idiotype vaccine strategies that have been tested in FL patients in frontline and relapsed settings to examine the safety and efficacy of this approach.

RESULTS

Several Phase II trials of recombinant or hybridoma-produced vaccines or vaccines combined with other immunotherapy demonstrate cellular and humoral anti-idiotype responses and clinical responses, indicating that idiotype vaccines provide promise for improving FL outcomes.

CONCLUSION

These strategies are now being evaluated in Phase III trials but have yet to demonstrate clear advantages in progression-free survival.