Investigational new drugs · 2014
Kidney injuries related to ipilimumab.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Izzedine Hassane, Gueutin Victor, Gharbi Chems, Mateus Christine, Robert Caroline, Routier Emilie, Thomas Marina, Baumelou Alain, Rouvier Philippe
Аннотация
Monoclonal antibodies directed against the immune checkpoint protein cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) have been investigated in metastatic melanoma and other cancers and have shown promising results. Inhibition of CTLA-4 characteristically induces well-known side effects called "immune-related adverse events" (irAEs). IrAEs mainly include colitis, dermatitis, hepatitis, endocrinopathies; uveitis, iridocyclitis, neuropathies, and inflammatory myopathy have occasionally been reported. Kidney involvement is rare. We report 2 cases of acute granulomatous interstitial nephritis and present, based on literature review, renal disorders related to Ipilimumab therapy. Autoimmune symptoms have to be carefully checked for patients treated with CTLA-4 inhibitors. In order to reduce the risk of sequelae, early recognition of irAEs and treatment initiation are crucial.