Aetiology and pathogenesis of non-Hodgkin lymphoma in AIDS.

The AIDS-NHLs constitute a histologically diverse group of tumours. Comparisons with some groups of non-AID-NHLs, including eBL, sBL and large cell lymphoma, have been made and similar pathogenetic mechanisms postulated for such groups. However, the incidence of the different pathological types of NHL in AIDS is not yet clear, and further work is necessary to determine the contribution of factors such as c-myc translocations and the presence of EBV. AIDS-NHLs are clearly a more diverse group of tumours than their non-AIDS counterparts, and this probably reflects the involvement of a whole range of different pathogenetic stimuli that occur in individual AIDS cases.