Fertility and sterility · 2010
Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation.
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Donnez Jacques, Squifflet Jean, Jadoul Pascale, Demylle Dominique, Cheron Anne-Céline, Van Langendonckt Anne, Dolmans Marie-Madeleine
Аннотация
OBJECTIVE: To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue.
DESIGN: Case report.
SETTING: Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels.
PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure.
INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity.
RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg.
CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.
DESIGN: Case report.
SETTING: Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels.
PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure.
INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation.
MAIN OUTCOME MEASURE(S): Restoration of ovarian activity.
RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg.
CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.