Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation.

OBJECTIVE

To report a live birth after orthotopic transplantation of cryopreserved ovarian tissue.

DESIGN

Case report.

SETTING

Department of Gynecology, Cliniques Universitaires Saint-Luc, Brussels.

PATIENT(S): Woman with metastatic cancer who had her ovarian tissue cryopreserved in 2001 before undergoing chemotherapy and hematopoietic stem cell transplantation, resulting in premature ovarian failure.

INTERVENTION(S): Orthotopic reimplantation of ovarian cortex performed 7 years after cryopreservation.

MAIN OUTCOME MEASURE(S): Restoration of ovarian activity.

RESULT(S): Restoration of ovarian activity was observed 3.5 months after reimplantantation, and ongoing pregnancy was diagnosed 9 months after grafting. The patient delivered a healthy baby weighing 2.830 kg.

CONCLUSION(S): Our patient represents the thirteenth live birth to occur after orthotopic reimplantation of cryopreserved tissue, but the first in a woman treated for metastatic disease.