Midfacial necrotizing lesion of the nasal cavity attributable to peripheral T-cell lymphoma.

The initial progression of a nonhealing ulcerative lesion in the nasopalatal region with nondiagnostic biopsy results, combined with progression of systemic symptoms, is suggestive of a PTL. Because therapy requires accurate histologic diagnosis, the clinician must be persistent to make a correct diagnosis. As the disease progresses, PTL histology matures, allowing diagnosis with immunohistochemical techniques. It is possible that earlier diagnosis will allow more timely treatment and a reduction in mortality related to this disease.