Cell reports · 2025
Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Moretti Chiara H, Grasset Estelle, Zhu Jiaying, Yang Gaohua, Olofsson Louise E, Khan Muhammad Tanweer, Bergh Per-Olof, Oh Jee-Hwan, Lundqvist Annika, van Gils Tom, Krämer Manuela, Olsson Lisa M, Patel Piyush, Mitteregger Matthias, Monges Daysi Espinola, Dwibedi Chinmay, Krautkramer Kimberly A, Koopman Nienke, Henricsson Marcus, Macpherson Andrew J, Schwartz Thue, Grompone Gianfranco, Pijkeren Jan-Peter van, Tremaroli Valentina, Roos Stefan, Simrén Magnus, Bäckhed Fredrik
Аннотация
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, which controls bowel motility. Functional bowel disorders, including irritable bowel syndrome, are associated with altered serotonin levels and gut microbiota composition. However, it is unclear if the gut microbiota can synthesize bioactive serotonin, which may affect enteric nervous system development. Here, we identify a consortium of the human gut bacteria Limosilactobacillus mucosae and Ligilactobacillus ruminis that synthesizes serotonin in vitro by decarboxylation of 5-hydroxytryptophan and elevates fecal serotonin levels, colonic neuronal density, and serotonin-immunoreactive neurons when introduced into germ-free, serotonin-deficient mice. The consortium normalizes intestinal transit time in germ-free wild-type mice, and we observe decreased fecal abundance of L. mucosae in individuals with irritable bowel syndrome. These findings suggest that specific members of the human gut microbiota synthesize bioactive serotonin that can contribute to gut health.