Acta oto-laryngologica · 2019
Rational choice of induction chemotherapy-based larynx preservation for hypopharyngeal cancer.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Liu Shuzhou, Fang Jugao, Ma Hongzhi, Meng Lingzhao, Bai Yunfei, Feng Ling, Lian Meng, Li Pingdong, Zhong Qi, Hou Lizhen
Аннотация
UNLABELLED: Backgroud: Induction chemotherapy, as a larynx preservation treatment, has been available for over 20 years. We conducted a retrospective study to evaluate the efficacy of this protocol with taxene, cisplatin and 5-fluorouracil in Chinese patients with hypopharyngeal cancer that chose preservation strategy.
MATERIAL AND METHODS: 170 patients with locally advanced hypopharyngeal cancer were assigned to receive induction chemotherapy. 107 patients (63%) with complete response or partial response received larynx preservation treatment and 63 non-responders (37%) received radical surgery.
RESULTS: Median survival time was 30 months (range: 3-59 months). 63 patients (37%) had local-regional failure and 15 (9%) had distant metastasis. Three-year LFS was 27.8% (95% CI: 23.6-32.0%). The estimated three-year overall survival rate was 44.5% (95% CI: 39.5-49.5%). There was no significant difference in the three-year survival rate between responders (44.8%) and non-responders (43.9%) (p = .237), however patients with a partial response had a significant decrease in survival (32.2%) (p < .001).
CONCLUSIONS: In patients with hypopharyngeal cancer, ICT with TPF regimen followed by RT, as a larynx preservation treatment, may be suitable for complete responders, but not partial responders.
MATERIAL AND METHODS: 170 patients with locally advanced hypopharyngeal cancer were assigned to receive induction chemotherapy. 107 patients (63%) with complete response or partial response received larynx preservation treatment and 63 non-responders (37%) received radical surgery.
RESULTS: Median survival time was 30 months (range: 3-59 months). 63 patients (37%) had local-regional failure and 15 (9%) had distant metastasis. Three-year LFS was 27.8% (95% CI: 23.6-32.0%). The estimated three-year overall survival rate was 44.5% (95% CI: 39.5-49.5%). There was no significant difference in the three-year survival rate between responders (44.8%) and non-responders (43.9%) (p = .237), however patients with a partial response had a significant decrease in survival (32.2%) (p < .001).
CONCLUSIONS: In patients with hypopharyngeal cancer, ICT with TPF regimen followed by RT, as a larynx preservation treatment, may be suitable for complete responders, but not partial responders.
Предметные рубрики MeSH
AdultAgedAntineoplastic Combined Chemotherapy ProtocolsBridged-Ring CompoundsCause of DeathChinaCisplatinCohort StudiesDisease-Free SurvivalFemaleFluorouracilFollow-Up StudiesHospitals, UniversityHumansHypopharyngeal NeoplasmsInduction ChemotherapyKaplan-Meier EstimateLaryngectomyLarynxMaleMiddle AgedNeoplasm Recurrence, LocalOrgan Sparing TreatmentsRetrospective StudiesRisk AssessmentStatistics, NonparametricSurvival AnalysisTaxoidsTime Factors