International journal of hematology · 2025
A case of acute promyelocytic leukemia complicated by mitochondrial disease.
СтатьяКлинический случайНазвание и аннотация: Перевод пока не подготовлен
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Sakurai Yukari, Yanagimachi Masakatsu, Ito Mieko, Hirose Ayana, Miyagawa Naoyuki, Keino Dai, Yokosuka Tomoko, Iwasaki Fuminori, Hamanoue Satoshi, Shiomi Masae, Goto Shoko, Goto Tomohide, Goto Hiroaki
Аннотация
A 15-year-old boy with congenital mitochondrial disease was diagnosed with acute promyelocytic leukemia. He was treated with all-trans retinoic acid, and his anthracycline dose was reduced in response to his underlying condition. He successfully achieved molecular remission and maintained this state for 4 years. In vitro drug sensitivity testing in peripheral mononuclear cells suggests that samples from patients in remission show higher sensitivity to various anticancer drugs than samples from healthy volunteers. Reduced-dose chemotherapy could be a valid treatment option for patients with mitochondrial diseases because exposure to elevated oxidative stress may contribute to increased drug sensitivity in these patients.