International journal of colorectal disease · 2025
Early- vs. late-onset colon cancer: clinicopathological insights and survival outcomes in an East Asian cohort.
Сравнительное исследованиеСтатьяНаблюдательное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Lin Chun-Chi, Chang Che-Yuan, Lin Yu-Zu, Cheng Hou-Hsuan, Huang Sheng-Chieh, Lin Hung-Hsin, Lan Yuan-Tzu, Wang Huann-Sheng, Chang Shih-Ching, Yang Shung-Haur, Jiang Jeng-Kai, Chen Wei-Shone, Teng Hao-Wei, Yang Yi-Wen
Аннотация
PURPOSE: Colorectal cancer (CRC) is the third most prevalent cancer worldwide, showing an increasing early-onset CRC in patients, which is defined as diagnoses made before the age of 50. Studies conflict on early-onset CRC prognosis versus late-onset CRC with varying survival outcomes. This study explores the age-related survival differences in colon cancer by comparing early- and late-onset groups.
METHODS: We performed a retrospective cohort study at a tertiary referral hospital (2010-2018), including 3459 patients with colon cancer (3076 late-onset, 383 early-onset). The clinicopathological features of early- and late-onset colon cancer were compared, and cancer-specific survival was evaluated using the Kaplan-Meier analysis with log-rank tests. The multivariate Cox regression identified independent prognostic factors.
RESULTS: Early-onset colon cancer showed female predominance, better Eastern Cooperative Oncology Group performance, more left-sided tumors, and advanced stages. On the contrary, late-onset patients had worse cancer-specific survival (hazard ratio 1.506, 95% confidence interval 1.147-1.977, p = 0.003), particularly in stages II/III, with tumor perforation, signet ring cells, or no perineural invasion.
CONCLUSION: In conclusion, despite early-onset colon cancer exhibiting more aggressive features, it is associated with better survival compared with late-onset cases. Further studies are required to validate these findings.
METHODS: We performed a retrospective cohort study at a tertiary referral hospital (2010-2018), including 3459 patients with colon cancer (3076 late-onset, 383 early-onset). The clinicopathological features of early- and late-onset colon cancer were compared, and cancer-specific survival was evaluated using the Kaplan-Meier analysis with log-rank tests. The multivariate Cox regression identified independent prognostic factors.
RESULTS: Early-onset colon cancer showed female predominance, better Eastern Cooperative Oncology Group performance, more left-sided tumors, and advanced stages. On the contrary, late-onset patients had worse cancer-specific survival (hazard ratio 1.506, 95% confidence interval 1.147-1.977, p = 0.003), particularly in stages II/III, with tumor perforation, signet ring cells, or no perineural invasion.
CONCLUSION: In conclusion, despite early-onset colon cancer exhibiting more aggressive features, it is associated with better survival compared with late-onset cases. Further studies are required to validate these findings.