Comparative Assessment of the Influence of Active Pharmacological Substances of Prostate Extract on the Contractile Activity of Rat Lymphatic Vessels.

The studied substances of the prostate extract have vasomotor activity of varying degree. The substance-mixture Prostatilen at concentrations of 2 and 5 μg/ml causes a positive chronotropic effect increasing the frequency of contractions by 23.7% (p ⩽ 0.01) and 37.6% (p ⩽ 0.01), respectively. The substance-powder Samprost did not affect motor activity of lymphatic vessels at a concentration of 2 μg/ml and inhibited the frequency of contractions by 6.7% (p ⩽ 0.05) at a concentration of 5 μg/ml. The substance Biofac at a concentration of 2 μg/ml has a negative effect on the motor activity of lymphangions changing the parameters of contractile activity in different directions, and at a concentration of 5 μg/ml it inhibits the contractile activity of lymphatic vessels (a 14.2% decrease in contraction frequency; p ⩽ 0.05).