[Effects of Suoquan Wan and Shenqi Wan on Urethra Function and β-AR Function of Detrusor in Natural Aged Rats].

OBJECTIVE

To investigate the effect of Suoquan Wan(SQW) and Jinkui Shenqi Wan(JKSQW) on urethra function and β6-AR function of detrusor in natural aged rats.

METHODS

young rats(3 months) and Aged rats(15 months) were chosen. Young rats were chosen as control, aged rats were randomly divided into three groups: model, JKSQW and SQW groups, 12 rats in each group. JKSQW and SQW were given the appropriate concentration once a day for six weeks. The effects of SQW and JKSQW on relaxation function of bladder detrusor was investigated, and their effects on bladder induced by β3-AR agonist and β3-AR agonist were further studied. Then, their effects on pressure of urethra were observed.

RESULTS

Compared with the young group, detrusor compliance of natural aged model rats was increased, Emax and IA of agonist of β3-AR including BRL37344 and ISO were decreased(P <0. 01), while PA2 of antagonist of β3-AR were increased(P <0. 05). Compared with model group, SQW and JKSQW decreased the bladder compliance(P <0. 05), and increased Emax, IA and PD2 due to sensitivity of detrusor to agonist of β3-AR and β3-AR including BRL37344 and ISO(P <0. 05 or P < 0. 01) ,while decreased PA2 of antagonist of β3-AR(P <0. 05). MUCP, MUP and FUL of aged rats were lower than those of normal rats. But SQW and JKSQW increased MUCP and MUP, and JKSQW increased FUL of aged rats(P <0. 05 or P <0. 01).

CONCLUSION

SQW and JKSQW can remarkably adjust β3-AR function on the detrusor and improve the closure ability of bladder detrusor of the natural aged rats.