Disorganisation of inner retinal layers in diabetic macular oedema: is it time to standardise this OCT biomarker?

Disorganisation of inner retinal layers (DRIL) is an optical coherence tomography (OCT) biomarker in patients with diabetic macular oedema. Different ways of quantification of DRIL have been proposed, without final agreement. We found a significant difference in DRIL length if measured with different techniques. Our data highlight that DRIL needs to be measured in a standardised way to provide comparable clinical results. Whereas an international consensus is needed, DRIL measurement as mean of five central OCT scans spaced 120 µm seems better than a single scan and comparable to seven scans, which needs a longer assessment time.