[Role intramural ganglion airway on action of histamine].

Influence of low concentration histamine on reactivity isolated trachea and bronchus preparations of rat induced field stimulation were studied. Application of 0.01-10 mkg histamine decreased responses preparation of trachea to 83% and bronchus to 79% at smooth muscle stimulation dose-depended manner. At postganglionic nerves stimulation histamine potentiated contraction of trachea without ganglions to 123%, trachea with ganglions to 110% and decreased contraction of bronchus to 87%. At stimulation ofpreganglionic nerves histamine evoked insignificant changes of contraction. With novocaine treatment of preparations histamine decreased responses of trachea by 19-30% at preganglionic stimulation, while responses of bronchus reduced by 8.2% only. Capsaicin treatment potentiated responses of trachea and bronchus on the effect of histamine induced preganglionic stimulation by 12-14%. We conclude that the action of histamine depends on the presence of ganglions and kind of stimulation. Different structures airways have various availability histamine-receptors and it determines the reaction of smooth muscle for histamine.