TGF-β signaling in the ovary: Emerging roles in development and disease.

The TGF-β superfamily plays a pivotal role in a wide array of cellular processes, including cell proliferation, differentiation, apoptosis, and migration. It is also critically involved in ovarian development and the pathogenesis of various diseases. Within the ovary, follicles act as the primary functional units, housing numerous members of the TGF-β superfamily that regulate follicular development and, consequently, overall ovarian function. Dysregulation of the TGF-β signaling pathway is associated with reproductive disorders and the development of ovarian diseases in female mammals, such as polycystic ovary syndrome (PCOS), premature ovarian aging, ovarian insufficiency, and ovarian cancer. This article highlights the significant contributions of key TGF-β signaling pathway members to follicular development and ovarian disease progression, aiming to deepen the understanding of TGF-β signaling's critical role in reproductive health.